Murine eosinophil differentiation factor. An eosinophil-specific colony-stimulating factor with activity for human cells.
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Murine eosinophil differentiation factor. An eosinophil-specific colony- stimulating factor with activity for human cells
A purified murine lymphokine, eosinophil differentiation factor (EDF), was found to be a selective stimulus for the clonal proliferation and differentiation of murine eosinophil progenitor cells, establishing it as the murine eosinophil colony-stimulating factor (Eo-CSF). EDF was also active on human eosinophil progenitors and mature blood eosinophils, but had no effect on neutrophil or macroph...
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Purified human blood eosinophils, when incubated in human placental conditioned medium (a source of colony-stimulating factors) [CSF]) demonstrate an enhanced ability to damage antibody- or complement-coated schistosomula. This enhancement represents a 4- to 10-fold increase of eosinophil schistosomicidal ability and a 10-fold lowering of the threshold for antibody or complement required in the...
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متن کامل[A case of pulmonary infiltration with eosinophilia syndrome with pleural effusion which contained eosinophil chemotactic factor and eosinophil colony stimulating factor].
緒言: PIE症 候群は好酸球の侵潤による肺実 質の炎症をきたす疾患であ り,一 般には胸部X線 写真における一過性の浸潤影および同時期の血中 好酸球増加に よって診断 される.我 々は胸水を 伴 ったPIE症 候群の1例 を経験 し,採 取した胸水 を用いて好酸球遊走活性,骨 髄における好酸球 コ ロニー形成 に及ぼす影響を検討 したので報告す る. 症例: 35才男性.昭 和50年 頃 より気管支喘 息で治療を受けていた.59年5月 より微熱,血痰 が 出現 し,胸 部X線 写真 で両側胸水を伴 う侵潤影を 認めた.好 酸球増加に関しては,末梢 血白血球で は11%と 軽度であったが,胸 水中では95%と 著明 に上昇 して いた.臨 床経過お よび検査所見 よ り PIE症 候 群(Crofton分 類1)で は'PIE with asthma')と 診断し,プ レドニゾロン3...
متن کاملStimulation of eosinophil production in vitro by eosinophilopoietin and spleen-cell-derived eosinophil growth-stimulating factor.
Eosinophilopoietin (EPP) was previously characterized by the ability to stimulate eosinophil production in vivo, but these studies could not ascertain whether EPP had a direct effect on the bone marrow or acted indirectly by causing release of eosinophilopoietic activity by other tissues. The present studies demonstrate that EPP stimulates eosinophil growth in liquid culture of mouse bone marro...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1986
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.163.5.1085